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Citation: JNS Volume 187, Supplement 1, page S256, June 2001
M.R. Kandil, H.M. Farweez, A. Aziz, M.A. Ahmed
Assiut University, Egypt
The benificial effect of thrombolytic therapy by different roots in acute stroke have been exposed to long debates. Little information are available about the use of intra-arterial urokinase therapy.
This study comprises thirty six patients admitted within 6 hours time window to the stroke unit of Assiut University Hospital "Egypt".
Patients were classified randomly to one line of treatment either non heparine conventional therapy (CT) or conventional plus thermpolitic therapy (by intra-arterial injection of urokinase 1000000 iu) (UT).
Risk factors: hypertension is more frequent in (CT) while diabetes, abnormal blood components and abnormal doppler findings are more frequent in (UT).
CT scan findings as regard the site, size and distribution of infarction proved to have a no significant differences between the 2 groups.
Clinical severity was assessed by the Scandinavian Stroke Scale (SSS). The number of mild/severe cases was (7:11) in the CT group and 3:15 in UT group.
Follow up of the clinical outcome using Barthel Index (BI) at 2 weeks, 3 months and 6 months was compared.
It declaired the superiority of the outcome of thrombolytic therapy group even with less death rate (4/6) over the conventional therapy group throughtout the follow up period.
At the end of 6 months follow up we have excellent outcome in 7/2 patients, good outcome in 4/5 patients and moderate to bad outcome in 3/5 patients in the UT/CT groups.
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